Sean Greene's work is driven by an interest in color interactions, and the sensations that result from visually absorbing them. He is currently exploring an imagined atmosphere inhabited by deeply-hued bands of light. As color realities in the form of light are so different from that of paint, he looks for unusual or surprising colors that appear to be convincing mixtures of their neighbors.

About his paintings Greene says "The forms I use are intuitive shapes that develop in the painting process. These forms give me a way to control the number of times colors mix, and locate areas of hot-ness or contrast, allowing me to create rhythm and balance within a sometimes tumultuous situation. I find deep satisfaction in the way that these forms imply typography, symbols, grafitti, and other forms of visual expression."